Hyper-Branched Dendrimers in Drug Delivery and Solubilization
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چکیده
periphery, which forms a closed membrane-like structure [3]. When a critical stage is reached dendrimers cannot grow because of steric hindrance. This is sometimes referred to as ‘starburst effect’. In case of PAMAM dendrimers the starburst effect can be observed after the tenth generation [4]. Number of terminal functional groups also increases exponentially with the increased branch density. These internal cavities and terminal functional groups play important role in controlling the properties of therapeutic moieties that are encapsulated or complexed with it [5].
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تاریخ انتشار 2015